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  • Title: Limited effect of magnesium sulphate on torsades de pointes ventricular tachycardia.
    Author: Toivonen LK, Leinonen H.
    Journal: Int J Cardiol; 1986 Aug; 12(2):260-2. PubMed ID: 3744606.
    Abstract:
    A patient with thioridazine-induced torsades de pointes ventricular tachycardia treated with magnesium sulphate is presented. Due to incessant recurrence of tachycardias it was possible to observe the time course of the effect of 1 g intravenous doses. Suppression of torsades de pointes lasted at best for no more than 18 min and a maintenance infusion was not effective without overdrive pacing. Magnesium sulphate may have value as first aid therapy for drug-induced torsades de pointes ventricular tachycardia. However, its effect disappears rapidly, and, therefore, should not alone be relied on as prophylactic treatment.
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