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  • Title: Medium-dose antacids versus cimetidine in the short-term treatment of duodenal ulcer.
    Author: Bianchi Porro G, Parente F, Lazzaroni M, Baroni S, Panza E.
    Journal: J Clin Gastroenterol; 1986 Apr; 8(2):141-5. PubMed ID: 3745847.
    Abstract:
    Seventy-eight patients with endoscopically proven duodenal ulcer were randomly allocated to be treated with a medium dose of liquid aluminum-magnesium antacid (75 ml in five daily doses) or cimetidine (400 mg twice daily) for 4 weeks in a prospective double-blind, double-dummy study. Healing rates at completion of trial were 66.7% in the cimetidine-treated group and 71.8% in the antacid group (p, ns). Both treatments were equally effective in relieving ulcer symptoms. Among the patient variables considered, only cigarette smoking was found to have a significant negative effect on ulcer healing. These results indicate that medium doses of antacids are as effective as cimetidine in the short-term treatment of duodenal ulcer.
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