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  • Title: [The alternation of peripheral lymphocyte subsets in head and neck carcinoma].
    Author: Mitarai K, Tsukuda M, Mochimatsu I, Kubota A, Sawaki S.
    Journal: Gan No Rinsho; 1986 Jul; 32(8):849-54. PubMed ID: 3747146.
    Abstract:
    Peripheral lymphocyte subsets of 115 patients with head and neck carcinomas were examined by the monoclonal antibody technique. In fresh tumor-bearing, the OKT 4 rate was decreased (P less than 0.01) and the OKT 8 rate was increased (P less than 0.05). Consequently the OKT4/OKT8 ratio was decreased (P less than 0.01) compared with normal healthy individuals. This result shows the abnormality of cellular immunity in carcinoma cases. The OKT4/OKT8 ratio reflected the clinical stages and courses sufficiently and correlated with other immunological parameters. The OKT4/OKT8 ratio is considered to be one of the parameters for elucidating the clinical conditions and immunities of carcinoma patients.
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