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  • Title: Repeated neurotensin administration in the ventral tegmental area: effects on baseline and D-amphetamine-induced locomotor activity.
    Author: Elliott PJ, Nemeroff CB.
    Journal: Neurosci Lett; 1986 Jul 24; 68(2):239-44. PubMed ID: 3748452.
    Abstract:
    Microinjections of neurotensin (NT) into the ventral tegmental area (VTA) of the rat increases locomotor activity. This effect on locomotion is potentiated by daily infusions of NT; in contrast a different injection schedule, i.e. every 48 h, had no such effect. In addition, daily NT injections in the VTA do not alter the locomotor response to a relatively low dose (0.5 mg/kg) of D-amphetamine. These results provide further evidence that NT can modulate the mesolimbic dopamine pathway.
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