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  • Title: Effect of bile on cyclosporine absorption in dogs.
    Author: Venkataramanan R, Perez HD, Schwinghammer T, Burckart GJ, Ptachcinski RJ, Van Thiel DH, Starzl TE.
    Journal: Res Commun Chem Pathol Pharmacol; 1986 Jul; 53(1):137-40. PubMed ID: 3749608.
    Abstract:
    Oral absorption of cyclosporine was studied in dogs with and without bile diversion. Blood and bile cyclosporine concentrations were determined by a high pressure liquid chromatographic method. The absorption of cyclosporine was significantly impaired (p less than 0.05) in dogs with bile diversion. Bile and bile salts appear to be essential for the absorption of cyclosporine.
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