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  • Title: Additional methylation at the N(2)-position of the cap of 26S Semliki Forest virus late mRNA and initiation of translation.
    Author: van Duijn LP, Kasperaitis M, Ameling C, Voorma HO.
    Journal: Virus Res; 1986 Jul; 5(1):61-6. PubMed ID: 3751287.
    Abstract:
    Cap analysis of the late 26S Semliki Forest viral mRNA reveals that almost 30% of the caps possess both a methyl group at the N(7)-position and one at the N(2)-position. We have compared the degree of methylation of the caps of polysomal and non-polysomal 26S mRNA in order to check whether this feature is responsible for its translation late in infection. It was found that extra methyl groups on the caps cause a lower rate of initiation. Polysomal 26S mRNA contained less m2,7G- and m2,2,7G-caps than free 26S. The cap analog m2,2,7Gp was slightly less inhibitory than m7Gp in an in vitro translation system.
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