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  • Title: Pharmacokinetics of metronidazole given to horses by intravenous and oral routes.
    Author: Sweeney RW, Sweeney CR, Soma LR, Woodward CB, Charlton CA.
    Journal: Am J Vet Res; 1986 Aug; 47(8):1726-9. PubMed ID: 3752681.
    Abstract:
    Serum and peritoneal fluid concentrations of metronidazole were determined in 6 healthy adult horses given the drug (25 mg/kg) by IV or oral routes. The disposition of metronidazole in horses given the drug by the IV route conformed to a 2-compartment model with a distribution half-life of 0.16 hours, an elimination half-life of 2.9 hours, and a body clearance of 0.40 +/- 0.05 L/kg/hr. The oral absorption half-life was 0.40 hours, and the bioavailability, 85.0 +/- 18.6%. Peritoneal fluid concentrations were approximately equal to serum concentrations at all times, regardless of the route of administration. On the basis of reported minimal inhibitory concentrations for anaerobic bacteria, a dosage of 15 to 25 mg/kg given orally 4 times daily was recommended.
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