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  • Title: The action of AD6 on experimental arrhythmias and on action potentials of cardiac fibers.
    Author: Bertolino M, Prosdocimi M, Aporti F, Finesso M, Gorio A.
    Journal: Arch Int Pharmacodyn Ther; 1986 May; 281(1):66-78. PubMed ID: 3753098.
    Abstract:
    AD6 is a coumarinic derivative which increases both coronary blood flow and prostacyclin production, while it decreases platelet responsiveness. We tested its action on experimental cardiac arrhythmias. AD6 (2.5-10 mg/kg) was able to antagonize the arrhythmogenic action of aconitine in rats and of adrenaline in cats. AD6 action was also tested in vitro. The drug (20-50 microM) prolonged the functional refractory period of guinea-pig atrial and ventricular muscle and lengthened the refractory period shortened by hypoxia. Intracellular electrophysiological experiments showed that AD6 prolongs action potential duration (APD) of guinea-pig atrial myocardium, sino-atrial node and cat Purkinje fibers. The results obtained in vitro may explain the effect on experimental arrhythmias, therefore suggesting a protective action on cardiac rhythm disturbances.
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