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  • Title: [Structural changes in popliteal lymph nodes in the graft vs. host reaction to H-Y antigen in male C57BL/6-strain mice].
    Author: Sapin MR, Aminova GG, Rusina AK, Grigorenko DE, Volkova LV.
    Journal: Arkh Anat Gistol Embriol; 1986 Jul; 91(7):53-60. PubMed ID: 3753227.
    Abstract:
    Regional popliteal lymph nodes in intact, control and experimental (I, II, III groups, respectively) have been studied by means of the morphometric method in male C57Bl/6 line mice at the pick of the reaction produced by injection of spleen cells and mesenteric lymph nodes obtained from syngenic females and repeatedly immunized to H-Y antigen (10 animals in each group). Injection of the cell suspensions from the immunized and intact females of the C57Bl/6 mice result nearly in two-fold increasing mass of the regional popliteal node at the expense of enlarged size of all its zones. Changes in cytoarchitectonics of the node structural components result from redistribution of certain cellular elements. The essential changes in the cell composition of the lymph nodes in the II and III male groups are accompanied with an increasing part of the stromal reticular cells. Simultaneously, content of small lymphocytes decreases significantly. In the III group of mice there is a sharp increase in the content of young forms of the lymphoid line cells in all structural components of the node, as well as in eosinophilic granulocytes in medullary cords. In the dark cortical zone of the nodes (III group) there occur tissue basophils (mast cells), that, together with increasing number of acidophilic granulocytes and appearance of neutrophilic cells, demonstrates that there is an inflammatory reaction in the organ studied as a response to the lymphocytic suspension injected. In the experimental group of the animals a complete disappearance of plasma cells is noted in the node cortex, but some increase of their part takes place in the medullary cords.
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