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  • Title: Chemical synthesis of octadeoxyribonucleotides containing sequence-specific 3'-deoxy-3'-chlorouridine residues and 2'-5' internucleotide linkages by the phosphite chloridite approach.
    Author: Smrt J, Hoffmann C, Cech D, Rosenthal A.
    Journal: Biomed Biochim Acta; 1986; 45(5):K9-14. PubMed ID: 3753470.
    Abstract:
    3'-Deoxy-3'-chlorouridine has been chemically incorporated into two octanucleotides at various positions using in situ prepared phosphite chloridite intermediates. The behaviour of these modified selfcomplementary DNA fragments containing 2'-5' internucleotide bonds in the neighbourhood of 3'-deoxy-3'-chlororibose in respect to chemical sequencing, polynucleotide kinase and T4 DNA ligase has been studied.
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