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  • Title: Treatment of sexually transmitted diseases.
    Journal: Med Lett Drugs Ther; 1986 Feb 28; 28(708):23-8. PubMed ID: 3754031.
    Abstract:
    This paper outline the treatments of choice for sexually transmitted infections. Current treatment recommendations for gonorrhea reflect the emergence of tetracycline-resistant Neisseria gonorrhoeae and the increasing prevalence of penicillinase-producing strains that are resistant to penicillin. A single dose of amoxicillin is highly effectice against urethral or cervical gonorrhea caused by penicillin-susceptible strains; also effective is a new agent, ceftriaxone. However, neither of these agents is effective against Chlamydia trachomatis infection, which is present in about 45% of patients with gonorrhea. Thus, many clinicians also treat gonorrhea patients with a 7-day course of tetracycline or doxycycline, as recommended for treatment of Chlamydia. Treatment of pelvic inflammatory disease should include antimicrobial agents active against all possible etiologic organisms: C. trachomatis, N. gonorrhoeae, Mycoplasma hominis, facultative enteric gram-negative bacilli, and various anaerobic bacteria. Vaginal infections are best treated by making an etiologic diagnosis by microscopic examination of the discharge and then treating with the appropriate microbials. Metronidazole remains the treatment of choice for trichomoniasis; however, this drug is contraindicated during the 1st trimester of pregnancy. Parenteral penicillin G remains the drug of choice for treating all stages of syphilis. A table provides concise information on the drug of choice, dosage, and alternative treatments for the most common sexually transmitted diseases.
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