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  • Title: New aspects of the epigenetic regulation of EMT related to pulmonary fibrosis.
    Author: Wang XC, Song K, Tu B, Sun H, Zhou Y, Xu SS, Lu D, Sha JM, Tao H.
    Journal: Eur J Pharmacol; 2023 Oct 05; 956():175959. PubMed ID: 37541361.
    Abstract:
    Pulmonary fibrosis is a chronic and progressive fibrotic disease that results in impaired gas exchange, ventilation, and eventual death. The pro-fibrotic environment is instigated by various factors, leading to the transformation of epithelial cells into myofibroblasts and/or fibroblasts that trigger fibrosis. Epithelial mesenchymal transition (EMT) is a biological process that plays a critical role in the pathogenesis of pulmonary fibrosis. Epigenetic regulation of tissue-stromal crosstalk involving DNA methylation, histone modifications, non-coding RNA, and chromatin remodeling plays a key role in the control of EMT. The review investigates the epigenetic regulation of EMT and its significance in pulmonary fibrosis.
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