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  • Title: High-dose metoclopramide and dexamethasone as an antiemetic in chemotherapy of breast cancer.
    Author: Gez E, Goodman S, Isacson R, Gerra C, Sulkes A.
    Journal: Oncology; 1986; 43(3):173-5. PubMed ID: 3754627.
    Abstract:
    Twenty-six patients with breast carcinoma who experienced severe emesis due to chemotherapy were evaluated for the antiemetic efficacy of high-dose metoclopramide (HD-MCP) and dexamethasone (DXM). Most of the patients received the CMF (cyclophosphamide, methotrexate and 5-fluorouracil) combination chemotherapy. The MCP and DXM dosage were: 2 X 2 mg/kg and 2 X 0.2 mg/kg, respectively. In 41% of eighty evaluable courses, nausea and vomiting were eliminated altogether. The common side effects were: drowsiness, restlessness and diarrhea. HD-MCP and DXM are recommended in modified dose for preventing CMF chemotherapy induced emesis.
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