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  • Title: [Effect of thymalin on thrombocyte aggregation and the antiaggregation activity of the vascular wall in intact and thymectomized rats].
    Author: Kuznik BI, Makhakova GCh, Morozov VG, Pisarevskaia LI, Khavinson VKh.
    Journal: Farmakol Toksikol; 1986; 49(2):15-8. PubMed ID: 3754821.
    Abstract:
    Administration of immunomodulator thymalin to intact rats was shown to produce reduction of platelet aggregation ability and to exert no effect on antiaggregation activity of the aorta. Thymectomy resulted in an increase of platelet number and their aggregation ability and an increase of antiaggregation activity of the vessel wall in the rats. Thymalin administration to thymectomized rats normalizes platelet hemostasis parameters. The role of the thymus in the regulation of platelet hemostasis is discussed.
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