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  • Title: Effects of defibrotide on peripheral obliterative vascular diseases.
    Author: Ulutin ON, Ilhan-Berkel N, Tunali H, Ozer M, Balkuv-Ulutin S, Onsel C, Urgancioğlu I.
    Journal: Haemostasis; 1986; 16 Suppl 1():59-62. PubMed ID: 3754837.
    Abstract:
    Twenty-nine patients with atherosclerotic obliterative vascular disorder and 9 cases of Buerger's disease were treated with 600 mg defibrotide daily for 10 days and then three times weekly for 3 months. The response to therapy was evaluated from hemostatic parameters, venostasis test (cuff test), treadmill testing, and radionuclide arteriography. We observed increased pain-free intervals in daily life and during treadmill testing. There was also a significantly higher response in the cuff test and improved perfusion as seen by radionuclide arteriography.
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