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  • Title: Cross-regulatory interactions among pair-rule genes in Drosophila.
    Author: Harding K, Rushlow C, Doyle HJ, Hoey T, Levine M.
    Journal: Science; 1986 Aug 29; 233(4767):953-9. PubMed ID: 3755551.
    Abstract:
    The pair-rule genes of Drosophila are required for the subdivision of the developing embryo into a repeating series of homologous body segments. One of the pair-rule genes, even-skipped (eve), appears to be particularly important for the overall segmentation pattern since eve- embryos lack all segmental subdivisions in the middle body region. On the basis of homeo box cross-homology we have isolated a gene, S72, which probably corresponds to eve. In embryo tissue sections S72 transcripts show a periodic distribution pattern. The eve- phenotype appears to involve altered patterns of fushi tarazu and engrailed expression. These and other findings suggest that pair-rule gene expression might involve hierarchical cross-regulatory interactions.
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