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  • Title: Selective 1H-NMR relaxation investigations of membrane-bound drugs in vitro. 2. Angiotensin II.
    Author: Valensin G, Delfini M, Gaggelli E.
    Journal: Biophys Chem; 1986 Jun; 24(1):25-31. PubMed ID: 3755628.
    Abstract:
    Binding interactions between human angiotensin II and dipalmitoylphosphatidylcholine bilayer vesicles have been detected by measuring the selective proton spin-lattice relaxation rates of aromatic protons within the peptide. Involvement of the imidazole moiety of the His-6 residue has been demonstrated by the pH dependence of the NMR observables. A lower limit of the binding constant has been evaluated at 78.12 mol-1 dm3 for the interaction involving nonionic intermolecular forces between aromatic residues and the lipid matrix.
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