These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Tunable Non-Enzymatic Glucose Electrochemical Sensing Based on the Ni/Co Bimetallic MOFs.
    Author: Wang Q, Jia Q, Hu P, Ji L.
    Journal: Molecules; 2023 Jul 26; 28(15):. PubMed ID: 37570619.
    Abstract:
    Constructing high-performance glucose sensors is of great significance for the prevention and diagnosis of diabetes, and the key is to develop new sensitive materials. In this paper, a series of Ni2Co1-L MOFs (L = H2BPDC: 4,4'-biphenyldicarboxylic acid; H2NDC: 2,6-naphthalenedicarboxylic acid; H2BDC: 1,4-benzenedicarboxylic acid) were synthesized by a room temperature stirring method. The effects of metal centers and ligands on the structure, compositions, electrochemical properties of the obtained Ni2Co1-L MOFs were characterized, indicating the successful preparation of layered MOFs with different sizes, stacking degrees, electrochemical active areas, numbers of exposed active sites, and glucose catalytic activity. Among them, Ni2Co1-BDC exhibits a relatively thin and homogeneous plate-like morphology, and the Ni2Co1-BDC modified glassy carbon electrode (Ni2Co1-BDC/GCE) has the highest electrochemical performance. Furthermore, the mechanism of the enhanced glucose oxidation signal was investigated. It was shown that glucose has a higher electron transfer capacity and a larger apparent catalytic rate constant on the Ni2Co1-BDC/GCE surface. Therefore, tunable non-enzymatic glucose electrochemical sensing was carried out by regulating the metal centers and ligands. As a result, a high-sensitivity enzyme-free glucose sensing platform was successfully constructed based on the Ni2Co1-BDC/GCE, which has a wide linear range of 0.5-2899.5 μM, a low detection limit of 0.29 μM (S/N = 3), and a high sensitivity of 3925.3 μA mM-1 cm-2. Much more importantly, it was also successfully applied to the determination of glucose in human serum with satisfactory results, demonstrating its potential for glucose detection in real samples.
    [Abstract] [Full Text] [Related] [New Search]