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  • Title: Dantrolene and suxamethonium. The effect of pre-operative dantrolene on the action of suxamethonium.
    Author: Collier CB.
    Journal: Anaesthesia; 1979 Feb; 34(2):152-8. PubMed ID: 375768.
    Abstract:
    A single oral dose of dantrolene (100--150 mg) given at least 2 hr pre-operatively has been found to reduce significantly the strength of muscular fasciculations, the hyperkalaemia and the incidence of muscle pains following suxamethonium (from 56 to 4%) in a series of forty-eight patients compared with controls. The biceps EMG of the fasciculations was unchanged by dantrolene; the incidence of troublesome side effects was low (9%) and there did not appear to be any alteration in the duration of action of suxamethonium.
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