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  • Title: Conversion from intravenous to sustained-release oral theophylline in pediatric patients with asthma.
    Author: Clarke DF, Werbowsky OL, Grodin MA, Shargel L.
    Journal: Drug Intell Clin Pharm; 1986 Sep; 20(9):700-3. PubMed ID: 3757784.
    Abstract:
    A method for converting pediatric patients from intravenous aminophylline to sustained-release oral theophylline was evaluated in eight asthmatic children. The administration of Theo-Dur tablets two hours before discontinuation of a continuous intravenous aminophylline infusion resulted in a peak rise of 5.6 +/- 3.0 micrograms/ml over steady-state serum theophylline concentrations. This method of conversion is acceptable in children with equivalent oral and intravenous doses of theophylline and serum theophylline concentrations less than 15 micrograms/ml. Children with steady-state theophylline concentrations greater than 15 micrograms/ml are likely to develop concentrations exceeding the therapeutic range using this conversion method.
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