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  • Title: Growth of mixed erythroid-granulocytic colonies in culture derived from bone marrow of patients with paroxysmal nocturnal hemoglobinuria without addition of exogenous stimulator.
    Author: Issaragrisil S, Piankijagum A, Chinprasertsuk S, Kruatrachue M.
    Journal: Exp Hematol; 1986 Oct; 14(9):861-6. PubMed ID: 3758236.
    Abstract:
    Hematopoietic progenitor cell cultures were studied in 16 patients with paroxysmal nocturnal hemoglobinuria (PNH). Both erythroid and granulocyte-macrophage progenitors in the blood and bone marrow decreased despite hypercellular marrow. In eight out of 16 patients, mixed erythroid-granulocytic colonies were observed in the bone marrow cultures without erythropoietin and colony-stimulating factor. Removal of monocytes and T-lymphocytes before culture failed to abrogate spontaneous mixed-colony formation. Conditioned media prepared from blood and bone marrow of PNH patients could not promote the growth of mixed colonies in normal individuals. The autonomous, spontaneous mixed-colony formation in patients with PNH is an abnormality of PNH stem cells not described previously.
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