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  • Title: Application of a combined rosette-fluorescent test in studies on leukemia cells.
    Author: Stella-Hołowiecka B, Hołowiecki J, Szeruda-Rudzka E, Krawczyk-Kuliś M.
    Journal: Arch Immunol Ther Exp (Warsz); 1979; 27(1-2):165-70. PubMed ID: 375866.
    Abstract:
    In 13 healthy blood donors and 42 patients with leukemia and lymphosarcoma, the combined rosette-fluorescent test allowed simultaneous evaluation of peripheral blood lymphocytes and leukemia cells for presence of membrane immunoglobulins and sheep erythrocyte receptors. In healthy subjects, the mean value for T cells was 68 +/- 9%, for B cells 16 +/- 5%, for nonreceptor cells 15 +/- 8%, and for cells possessing both markers 0.6 +/-0.8%. In cases of acute leukemia, nonreceptor cells predominated (59 +/-24%), and values for T cells were usually low (19 +/- 13%). In chronic lymphocytic leukemias and lymphosarcoma, B and "null" cells usually predominated more or less. In all patients values for double-receptor cells were low. The combined test proved to be a convenient method for simultaneous evaluation of both markers. It is also useful for recognizing blastic leukemia cells devoid of both receptors and for determing values for T and B lymphocytes.
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