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  • Title: Amyloidosis in a dog: treatment with dimethylsulfoxide.
    Author: Spyridakis L, Brown S, Barsanti J, Hardie EM, Carlton B.
    Journal: J Am Vet Med Assoc; 1986 Sep 15; 189(6):690-1. PubMed ID: 3759637.
    Abstract:
    A dog with hypoalbuminemia, proteinuria, and renal amyloidosis was treated with dimethylsulfoxide for 2 years. During a 1-year period, serum albumin concentrations increased to within normal range. The 24-hour urinary protein excretion was 5.7 g before treatment with dimethylsulfoxide. Two years after initiation of treatment, the 24-hour urinary protein excretion was 3.7 g. Removal of a testicle containing a Sertoli cell tumor and treatment of interdigital pyoderma may have been factors in the dog's clinical improvement. The only adverse effect from the dimethylsulfoxide treatment was the characteristic disagreeable odor.
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