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  • Title: Spironolactone in the treatment of idiopathic hirsutism and the polycystic ovary syndrome.
    Author: Evans DJ, Burke CW.
    Journal: J R Soc Med; 1986 Aug; 79(8):451-3. PubMed ID: 3761287.
    Abstract:
    Forty-eight hirsute women were treated with spironolactone 100 mg twice daily for 3 to 12 months. Both facial and body hirsuties improved by 30-40%, and there was a threefold reduction in frequency of local treatments such as waxing or shaving. Plasma testosterone fell by 30%, though the improvement in hirsuties grading did not correlate with the fall in plasma testosterone. Six subjects discontinued treatment because of lack of effect, and 4 because of menstrual disturbance. Spironolactone was equally effective in the treatment of idiopathic hirsutism and of the polycystic ovary syndrome.
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