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  • Title: Mechanism of action of the marine natural product stypoldione: evidence for reaction with sulfhydryl groups.
    Author: O'Brien ET, Asai DJ, Groweiss A, Lipshutz BH, Fenical W, Jacobs RS, Wilson L.
    Journal: J Med Chem; 1986 Oct; 29(10):1851-5. PubMed ID: 3761306.
    Abstract:
    Stypoldione, a marine natural product that possesses an o-quinone functional group, has been shown to inhibit a variety of biological processes including cell division. We found that stypoldione binds covalently to sulfhydryl groups of thiol-containing compounds via addition of sulfur to the C-4' position of the quinone ring. We examined the ability of stypoldione to add to sulfhydryl groups of a number of thiol-containing substances, including glutathione, thiophenol, beta-mercaptoethanol, and the protein tubulin. We suggest that the biological actions of stypoldione may be caused by the addition of this compound to thiol groups of biological molecules.
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