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  • Title: Pharmacokinetics and diuretic effect of bumetanide following intravenous and intramuscular administration to horses.
    Author: Delbeke FT, Debackere M, Desmet N, Stevens M.
    Journal: J Vet Pharmacol Ther; 1986 Sep; 9(3):310-7. PubMed ID: 3761422.
    Abstract:
    Concentrations of the potent diuretic bumetanide were determined by a sensitive high performance liquid chromatographic procedure in plasma and urine from horses following intravenous and intramuscular administration of a dose rate of 15 micrograms/kg. The elimination half-life was found to be 6.3 min, the volume of distribution at steady state 68 ml/kg and the total plasma clearance 10.9 ml/min/kg. The onset of diuresis occurred within 15 min and diuresis was no longer apparent 1 h after i.v. administration. Given by the intramuscular (i.m.) route, bumetanide was rapidly absorbed; bioavailability was 70-80%. i.m. administration of bumetanide prolonged its plasma half-life (11-27 min) and enhanced and prolonged its diuretic effect.
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