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  • Title: Influence of naloxone upon apomorphine-induced rotational behavior in rats with electrolytic versus chemolytical lesions of the substantia nigra.
    Author: Quock RM, Sadowski JA.
    Journal: Pharmacol Res Commun; 1986 Jul; 18(7):663-72. PubMed ID: 3763674.
    Abstract:
    In rats with unilateral electrolytic lesions of the substantia nigra, apomorphine induced ipsilateral rotational behavior that was significantly potentiated by naloxone. Yet, in rats with unilateral chemolytic (6-hydroxydopamine) lesions of the substantia nigra, apomorphine induced dose-dependent contralateral turning that was not influenced by pretreatment with even high doses of naloxone. High performance liquid chromatographic analysis of corpora striata from these rats revealed electrolytically-lesioned animals to have a 60-70% reduction in dopamine content while chemolytically-lesioned animals were virtually completely depleted of dopamine. These results suggest that striatal dopamine may be required for naloxone potentiation of apomorphine-induced effects in the rat rotational behavior paradigm.
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