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  • Title: Methotrexate increases glycogenolysis in the intact rat liver.
    Author: de Oliveira MB, Ishii EL, Yamamoto NS, Bracht AM, Campello Ade P, Kluppel ML, Bracht A.
    Journal: Res Commun Chem Pathol Pharmacol; 1986 Aug; 53(2):173-81. PubMed ID: 3764081.
    Abstract:
    The effect of methotrexate, an anti-cancer drug, on carbohydrate metabolism in the isolated perfused rat liver was investigated. Glucose release from endogenous glycogen (glycogenolysis) is strongly activated by methotrexate. The phenomenon shows a well defined concentration dependence: 100% activation occurs at 2.2 X 10(-4) M. Glycolysis and oxygen consumption are only slightly affected.
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