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  • Title: [Comparative evaluation of the clinical course and dynamics of the morphological changes in chronic glomerulonephritis].
    Author: Tov NL, Valentik MF, Vlazneva VA, Kagalovskaia IM, Nesina IA.
    Journal: Ter Arkh; 1986; 58(8):10-3. PubMed ID: 3764748.
    Abstract:
    The results of a simultaneous study of a clinical and morphological course of chronic glomerulonephritis (CGN) in 30 patients after repeated morphological investigation of the renal tissue showed that a prevailing tendency in this disease was the progression of morphological changes which could be noted in a stable clinical picture and even in clinical improvement. The detection of tubulointerstitial changes in the first nephrobiopsy was an unfavorable prognostic factor. Of the greatest importance for indirect assessment of a morphological course of CGN were changes in creatinine clearance, effective renal plasma flow and arterial pressure. A morphological course of different variants of CGN and the effect of pathogenetic therapy on it were analyzed.
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