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  • Title: The immune response during proliferative kidney disease in rainbow trout: a case history.
    Author: Klontz GW, Rourke AW, Eckblad W.
    Journal: Vet Immunol Immunopathol; 1986 Jun; 12(1-4):387-93. PubMed ID: 3765361.
    Abstract:
    Young-of-the-year rainbow trout clinically affected by proliferative kidney disease (PKD), a systemic protozoan infection, exhibit a massive proliferation of small lymphocytes in the posterior kidney and spleen, a decrease in erythrocyte packed cell volume, hemoglobin, and serum albumins and an increase in beta-globulins. Electronphotomicrographs of the causative agent indicate that it is engulfed within a macrophage which is surrounded by small lymphocytes. Fish having survived a clinical episode are completely refractory to subsequent infection. Their serum electrophoretic patterns are quite unremarkable.
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