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  • Title: [Immunoreactivity and the effect on it of the 3-HAA antigen in patients with gastrointestinal tumors].
    Author: Korosteleva TA, Mel'nikov RA, Belokhvostova AT, Movsesian KS, Skadova VM.
    Journal: Vopr Onkol; 1986; 32(8):38-45. PubMed ID: 3765508.
    Abstract:
    3-hydroxyanthranilic acid(3-HAA)-antigen, commonly identifiable in blood serum of gastrointestinal cancer patients was shown to influence immunologic vigor in vitro. Treatment of patients' cultured lymphocytes with 3-HAA-antigen and PHA produced a statistically significant inhibition of blastogenic reaction of lymphocytes. Exposure to the said antigen gave a positive leukocyte migration inhibition test both in patients and controls. Antibodies against 3-HAA-antigen were identified in patients' serum by complement fixation test. Blood serum levels of the said antibodies and IgG were found to be in correlation with blood-3-HAA-antigen concentration. Patients' serum revealed an immunosuppressive activity inhibiting formation of antibody-producing cells to sheep erythrocytes in Jerne assay in mice.
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