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  • Title: [Role of splenectomy in impairing lymphocyte elimination in patients with lymphogranulomatosis].
    Author: Kuz'mina EG, Bogatyreva TI, Baĭsogolov GD, Iarilin AA.
    Journal: Vopr Onkol; 1986; 32(8):65-8. PubMed ID: 3765511.
    Abstract:
    The study group included 113 patients in a continuing 1 to 10 year-long complete clinical-hematological remission from Hodgkin's disease. 43 of them had prior splenectomy. The latter revealed a higher level of lymphocytes (chiefly 0-cells) and a diminished response of mononuclear blood cells to PHA as compared to the other patients and healthy controls. Also, they had more lymphocytes which became capable of E-rosette formation following a short-term incubation at 37 degrees C (lymphocyte reactivation by means of surface modification). The negative correlation between the reactivated T-cells level and mononuclear cell response to PHA suggested a functional blocking of T-cells involving damage to membranes. The absence of reactivated T-lymphocytes in nonsplenectomized patients was regarded as circumstantial evidence for the role played by the spleen in withdrawing faulty lymphocytes from peripheral blood.
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