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  • Title: Poly(ADP-ribose) effectively competes with DNA for histone H4 binding.
    Author: Sauermann G, Wesierska-Gadek J.
    Journal: Biochem Biophys Res Commun; 1986 Sep 14; 139(2):523-9. PubMed ID: 3767974.
    Abstract:
    The effect of poly(ADP-ribose) on DNA-histone H4 interaction was studied using a nitrocellulose filter binding assay. Poly-(ADP-ribose) was found to form poly(ADP-ribose)-histone H4 complexes at physiological salt concentrations. The homopolymer effectively competed with DNA for histone H4 binding. Poly(ADP-ribose) was also capable of displacing DNA from preformed DNA-histone H4 complexes. Our hypothesis is that poly(ADP-ribose), locally and transiently formed at the site of DNA damage, causes dissociation of DNA from the nucleosome particle or nucleosome unfolding.
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