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  • Title: Paracetamol metabolism in pregnancy.
    Author: Miners JO, Robson RA, Birkett DJ.
    Journal: Br J Clin Pharmacol; 1986 Sep; 22(3):359-62. PubMed ID: 3768250.
    Abstract:
    Paracetamol disposition was studied in groups of pregnant and non-pregnant women of comparable age. Paracetamol apparent oral clearance was 58% higher and elimination half-life was 28% lower in the pregnant women compared to the control group. The higher clearance in the pregnant women was due to increased activity of the glucuronidation (75% higher) and oxidative (88% higher) pathways of paracetamol metabolism. There was no difference between the two groups in paracetamol sulphation or renal clearance of unchanged drug.
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