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  • Title: [Assessment of the erythropoietin-producing function of the kidney and liver under controlled perfusion].
    Author: Nefedov VP, Makarov VP, Tashenov EK, Krizhanovskaia EV, Kazakov VN.
    Journal: Biull Eksp Biol Med; 1986 Oct; 102(10):404-6. PubMed ID: 3768502.
    Abstract:
    The balance of erythropoietin production by the dog kidney and liver was studied during controlled normoxic perfusion. The hormone production was stimulated by acute posthemorrhagic anemia (bloodletting of 25% total blood volume) combined with subcutaneous injection of cobaltous chloride (250 microM/kg body weight). The increase in erythropoietin level was revealed in posthypoxic animal perfusate after 6 hours of perfusion. The amount of hepatic erythropoietin was shown to be 2.5 times higher than that excreted by kidneys.
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