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  • Title: Vancomycin-induced neutropenia during treatment of osteomyelitis in an outpatient.
    Author: Henry K, Steinberg I, Crossley KB.
    Journal: Drug Intell Clin Pharm; 1986 Oct; 20(10):783-5. PubMed ID: 3769768.
    Abstract:
    A case of vancomycin-associated neutropenia occurring during long-term outpatient therapy with vancomycin is described. Pharmacokinetic studies demonstrated that the patient's vancomycin serum levels were within an acceptable range during treatment. Eighteen other reported cases of vancomycin-associated leukopenia are discussed in brief. An immunologic mechanism has been proposed but a clear understanding is lacking. Patients receiving long-term vancomycin therapy should have their white blood cell counts periodically monitored.
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