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  • Title: [Determination of the digoxin concentration in the blood plasma of patients with cardiopulmonary failure].
    Author: Sidorova LD, Arkhipova GF, Kudelia LM, Pavlova IP.
    Journal: Farmakol Toksikol; 1986; 49(5):22-5. PubMed ID: 3770167.
    Abstract:
    Digoxin was used for 2-4 weeks in a combined treatment of 98 patients with cardiopulmonary insufficiency. Blood plasma digoxin concentration was measured in 65 patients. A clinical improvement accompanied with positive hemodynamic changes, an improvement of myocardial contractility, a decrease of pulmonary hypertension was observed in 88% of patients. The relationship between a clinical effect and the drug dose was found. Correlation between blood digoxin concentration, stage of circulatory insufficiency and toxic manifestations was revealed.
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