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  • Title: Nicotine-evoked disassembly of cortical actin filaments in adrenal chromaffin cells.
    Author: Cheek TR, Burgoyne RD.
    Journal: FEBS Lett; 1986 Oct 20; 207(1):110-4. PubMed ID: 3770186.
    Abstract:
    Using rhodamine-phalloidin staining it was found that actin filaments are concentrated in the cortex of resting chromaffin cells. Cortical actin filaments were disassembled 15 s after stimulation by nicotine and had reassembled 30 s later. Actin filament disassembly following nicotinic stimulation was also detected using the DNase I inhibition assay. Disassembly was independent of external calcium, insensitive to trifluoperazine and was not elicited by high K+, muscarinic agonists or phorbol ester. Disassembly of cortical actin filaments may allow access of secretory granules to exocytotic sites and act in conjunction with a rise in intracellular free calcium to bring about the full secretory response due to nicotinic agonists.
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