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  • Title: Preparation and biodistribution of 99mTc chelate of strophanthidin--a cardiac aglycone.
    Author: Misra M, Banerjee SN.
    Journal: Int J Rad Appl Instrum B; 1986; 13(1):75-7. PubMed ID: 3771241.
    Abstract:
    Cardiac glycosides are well known to exert a specific and powerful effect on myocardial tissue, and there is a possibility that this class of compound with a 99mTc radiolabel may behave as a superior myocardial imaging agent in comparison to 201Tl which is at present used clinically. Because of the extreme chemical complexity of cardiac glycosides a simpler aglycone, strophanthidin was selected as the pilot compound for preliminary labelling and in vivo distribution studies. Strophanthidin was converted to 19-thiosemicarbazone which nicely accommodated 99mTc to produce a pure radiopharmaceutical of high specific activity. The distribution pattern in animal models was studied which is in accordance with the metabolic studies performed earlier with the ligand itself.
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