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  • Title: Daphnepedunins G and H, anti-HIV macrocyclic 3,4-seco-daphnane orthoesters from Daphne pedunculata.
    Author: Tan L, Otsuki K, Zhang M, Kikuchi T, Zhou D, Li N, Huang L, Chen CH, Li W.
    Journal: J Nat Med; 2024 Jan; 78(1):114-122. PubMed ID: 37713094.
    Abstract:
    Daphnepedunins G (1) and H (2) with unusual macrocyclic 3,4-seco-daphnane orthoester structure were isolated from Daphne pedunculata. Their structures were determined by physicochemical and spectroscopic analyses combined with synthetic methods, including methyl esterification, derivatization reaction using a chiral anisotropic agent, and biomimetic conversion. Compounds 1 and 2 along with their methyl esters 1a and 2a were evaluated for anti-HIV activity, among which 1a and 2a exhibited potent activity with IC50 values of 1.08 and 1.17 μM, respectively.
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