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  • Title: [Consumption coagulopathies following peritoneojugular bypass. Prevention by a heparin-antithrombin III combination].
    Author: Peyrin JC, Waldmann V, Girardet P, Pouzol P, Duret J, Fargnoli JM, Magne JL, Perron Y.
    Journal: J Chir (Paris); 1986; 123(6-7):417-23. PubMed ID: 3771670.
    Abstract:
    Consumption coagulopathy (CIVD) is a frequent complication of peritoneojugular bypass operation. Preventive treatment applied involves low-dose heparin (1.5 mg/kg/d) to maintain an antithrombin III concentration of at least 65%. Results are evaluated in 6 patients treated by 7 bypass operations. A biologic CIVD developed in 2 cases (29%) but no clinical coagulopathy was observed. This incidence is less than that usually reported, a literature review indicating a biologic coagulopathy in 65% of cases, with clinical evidence in 12.5%. Furthermore, patients with spontaneously elevated AT III levels did not develop CIVD while, in contrast, sufficiently high concentrations of AT III could not be maintained in the 2 patients with coagulopathy. These findings suggest the interest of prevention of a CIVD by the use of this procedure.
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