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  • Title: Interactions between cimetidine, methylparathion, and parathion.
    Author: Joshi UM, Thornburg JE.
    Journal: J Toxicol Environ Health; 1986; 19(3):337-44. PubMed ID: 3772983.
    Abstract:
    The purpose of this study was to determine whether cimetidine exerts a protective effect against toxicity of organophosphate pesticides requiring metabolic activation in mice and rats. In both species, pretreatment with cimetidine (75 mg/kg/ip) 30 min prior to methylparathion (MP) reduced lethality and delayed the onset of cholinergic signs of toxicity. In contrast when cimetidine was administered simultaneously with MP to mice, neither MP-induced lethality nor cholinergic signs of toxicity were altered. Moreover, cimetidine pretreatment failed to decrease parathion-induced toxicity in mice. In conclusion, pretreatment with cimetidine decreases the toxicity of MP but not of parathion in mice and rats.
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