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  • Title: Automated radiosynthesis of [18F]FMPEP-d2 for cannabinoid receptor PET imaging.
    Author: Jiang H, Guo Y, Muzik O.
    Journal: Am J Nucl Med Mol Imaging; 2023; 13(4):171-178. PubMed ID: 37736496.
    Abstract:
    The cannabinoid subtype 1 receptor (CB1R) is highly expressed in the central nervous system and abnormalities in regional CB1R density are associated with neurodegenerative disorders. The PET tracer [18F]FMPEP-d2 is an inverse CB1R agonist which was shown to be suitable for non-invasive PET imaging. In this work, we reported the fully automated radiosynthesis of [18F]FMPEP-d2 on a Synthra RNplus research module. In a total synthesis time of 70 min, [18F]FMPEP-d2 was obtained in 2.2 ± 0.1 GBq (n = 3) with excellent radiochemical and chemical purity. Quality control test showed that [18F]FMPEP-d2 product meets all the release criteria for clinical patient use.
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