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  • Title: Bioactive phytochemicals from the tubers of Bletilla striata Rchb.f.
    Author: Lee CL, Jhan YL, Chiang HM, Chen CJ.
    Journal: Nat Prod Res; 2024 Nov; 38(21):3848-3853. PubMed ID: 37740591.
    Abstract:
    Thirty-four phytochemicals were isolated from dry tubers of Bletilla striata Rchb.f. The compounds were classified as bibenzyls 1-14, dihydrophenanthrenes 15, 17, 20, 21, phenanthrenes 16, 18, 19, simple benzoids 22-24, a fatty acid 25, glucosyloxybenzyl 2-isobutylmalates 26-32, and glucosyloxybenzyl cinnamates 33, 34. Compounds 1-4, 7, 8, 11, 12, and 16 inhibited melanogenesis (17.96-55.27%) induced by α-MSH in B16F10 cells at 10-40 μM. However, compounds 9, 10, 17, 18, and 21 exhibited significant cytotoxicity against melanomas, with IC50 values of 12-34 μM. Additionally, compounds 15, 17, 19, 20, 23, 31, and 33 reduced the ROS generation induced by H2O2 in HaCaT cells at 6.25-100 μM. In particular, compounds 15, 19, and 20 strongly inhibited ROS generation, with IC50 values of 2.15-9.48 μM. Consequently, compounds 1-4, 7-12, and 15-21 may be the strongest leads to follow in B. striata extract for further research on the skin disorders, hyperpigmentation, melanoma, and ageing.
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