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  • Title: Influence of delta-sleep inducing peptide on melatonin synthesis in the rat pineal gland.
    Author: Oaknin S, Troiani ME, Webb SM, Reiter RJ.
    Journal: Neurosci Lett; 1986 Sep 25; 70(1):127-31. PubMed ID: 3774211.
    Abstract:
    The influence of delta-sleep inducing peptide (DSIP) on rat pineal N-acetyltransferase (NAT) activity and melatonin levels was examined. Young adult rats received an injection of either saline or DSIP (either 15, 30 or 60 nmol/kg) at 20:00 h, immediately before lights out. DSIP at a dose of 15 nmol/kg significantly retarded the nighttime rise of pineal NAT activity and melatonin levels at 3 h into the dark phase. At the other two nocturnal time points (01:00 and 03:00 h) and the following morning (08:00 h) pineal NAT activity and melatonin levels were similar in all groups. The results confirmed a short-lived, dose-specific effect of DSIP on serotonin metabolism in the rat pineal gland.
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