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  • Title: A double-blind cross-over evaluation of ketoprofen (Orudis) and ibuprofen in the management of rheumatoid arthritis.
    Author: Montrone F, Fumagalli M, Pellegrini P, Ratti G, Sala G, Liverta C, Pollini C, Pontiroli AE.
    Journal: Rheumatol Rehabil; 1979 May; 18(2):114-8. PubMed ID: 377448.
    Abstract:
    In a multi-centre double-blind cross-over trial using the double-placebo technique, 55 patients with rheumatoid arthritis were treated for 10 days for each trial drug with ketoprofen (200 mg/day) and ibuprofen (1200 mg/day). Both drugs induced a clinically and statistically significant improvement of all the symptoms studied, except for pain at night during ibuprofen administration. Ketoprofen displayed a therapeutic efficacy significantly superior to ibuprofen in five of the eight symptoms studied. Side-effects were recorded in 10 patients receiving ketoprofen (one patient withdrew because of heartburn) and in nine patients receiving ibuprofen.
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