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  • Title: The effects of apomorphine on leverpress shock escape learning in rats.
    Author: Mattingly BA.
    Journal: Pharmacol Biochem Behav; 1986 Sep; 25(3):693-5. PubMed ID: 3774836.
    Abstract:
    Four groups of rats (n = 10 each) were tested on a discrete trial leverpress shock escape task 15 min following an intraperitoneal injection of either 0 (saline), 0.5, 1.0, or 2.0 mg/kg apomorphine hydrochloride. The results indicated that all doses of apomorphine produced a severe disruption in escape performance. This disruption was temporary, however, as all apomorphine groups were responding as quickly as the saline control rats by the end of the training session. A comparison of the effects of apomorphine with the previously reported effects of scopolamine and septal lesions on shock escape learning revealed both similarities and differences. These findings suggest that a septal lesion-induced reduction of acetylcholine levels does not simply "unleash" an antagonistic dopaminergic system.
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