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  • Title: Pharmacological control of the in vivo passive anaphylactic shock by the PAF-acether antagonist compound BN 52021.
    Author: Vilain B, Lagente V, Touvay C, Desquand S, Randon J, Lefort J, Braquet P, Vargaftig BB.
    Journal: Pharmacol Res Commun; 1986 Aug; 18 Suppl():119-26. PubMed ID: 3774840.
    Abstract:
    BN 52021 antagonized PAF-acether-induced bronchoconstriction (BC) in the guinea-pig and inhibited BC triggered by antigen in passively sensitized animals. The anti-anaphylactic activity was prevented by propranolol and may either result from an additional property of the drug, independent from PAF antagonism or from different PAF-dependent mechanisms with different responsiveness to the various antagonists.
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