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  • Title: [Enhancement by metronidazole of the antitumor effect of cyclophosphane].
    Author: Riabchenko NI, Smoryzanova OA, Proskuriakov SIa, Dedenkov AN.
    Journal: Radiobiologiia; 1986; 26(5):661-3. PubMed ID: 3774977.
    Abstract:
    In experiments on mouse tumors (sarcoma-180, Ehrlich ascites tumor and hemoblastosis La) the ability of metronidazole to enhance the antitumor chemotherapeutic action of cyclophosphane was investigated. It was shown that metronidazole (1000 mg/kg) injected 60 min before cyclophosphane administration can elicit an almost two-fold increase in its radioprotective efficiency. The chemosensitizing effect of metronidazole depends on the drug concentration and the tumor type.
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