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  • Title: Antibodies to dietary antigens in coeliac disease.
    Author: Volta U, Lazzari R, Bianchi FB, Lenzi M, Baldoni AM, Cassani F, Collina A, Pisi E.
    Journal: Scand J Gastroenterol; 1986 Oct; 21(8):935-40. PubMed ID: 3775259.
    Abstract:
    Antibodies to gliadin (AGA) were found in 77 (94%) of 82 sera from patients with active coeliac disease (untreated and after gluten challenge). Although IgG AGA had a higher nosological sensitivity than IgA AGA (88% versus 67%), their nosological specificity was lower than that of IgA antibodies (87% versus 100%). The sensitivity of antibodies to casein, beta-lactoglobulin, and ovalbumin in active coeliac disease varied from 36% to 48% without significant difference between IgG and IgA antibodies. IgG and IgA antibodies to milk and egg proteins showed a specificity similar to that of AGA, although some IgA antibodies other than AGA were found in disease controls (Crohn's disease, ulcerative colitis, post-enteritis syndrome).
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